Research overview
The Vos Lab studies how genome organization influences gene expression, specifically to drive cell type specificity. We study how transcription and genome organization are physically coupled using structural biology and biochemistry. This includes X-ray crystallography, cryo-EM, and biophysical approaches.
Local genome organization
Local genome organization is driven by chromatin and its post-translational modification. We are interested in understanding how molecular machines that modify chromatin influence transcription.
Global genome organization
Genomes from bacteria to humans are segregated into transcriptionally active and inactive regions through the formation of large, loop-like structures. We are interested in understanding how these loops are formed and how transcription directly affects loop formation and stability.